One of the coolest museums in New York, Rose Center For Earth and Space is being attacked by Doctor Octopus in "Spider Man 2".
You can't have a super hero film set in Manhattan and don't have any scene at Central Park. And it's quite a sad scene: Mary Jane tells Peter that she is going to marry his best friend. They talk on one of the most beautiful bridges of Central Park, Bow Bridge. Don't miss it.
Spidey can be seen on Times Square quite often. In the first installment of Sam Raimi trilogy he came here to fight the Green Goblin. You may have dozens of other reasons to be here.
One of the iconic New York buildings in Spider Man universe is home to the Daily Bugle, a newspaper where Peter Parker works as a photographer. Daily Bugle is fictional media, but it doesn't make Flatiron less attractive, so just go there.
This decorated Neo-Gothic-style Roman Catholic cathedral church is one of the most important churches in New York. It is featured in "Spider Man", when Peter saves Mary Jane and takes her down near the cathedral. Very romantic indeed.
Hungry? Have a pizza at Joe's Pizza, where Peter Parker worked as a delivery man in the second film.
Not the must-see park in a city that has Central, but worth to have a rest if you're around. Or check your watches with the clock near it.
One of many Manhattan squares, with Thurgood Marshall United States Courthouse, Daniel Patrick Moynihan United States Courthouse and New York County Supreme Court. The latest becomes a target of villains during the Spidey themed fest in the third film. But usually it's peaceful and pleasant.